| First Author | Koyama Y | Year | 2006 |
| Journal | Brain Res | Volume | 1112 |
| Issue | 1 | Pages | 65-9 |
| PubMed ID | 16901473 | Mgi Jnum | J:113022 |
| Mgi Id | MGI:3664355 | Doi | 10.1016/j.brainres.2006.07.013 |
| Citation | Koyama Y, et al. (2006) Expression of prokineticin receptors in mouse cultured astrocytes and involvement in cell proliferation. Brain Res 1112(1):65-9 |
| abstractText | Effects of prokineticins (PKs), a novel family of bioactive peptides with a mitogenic action to endothelial cells of the endocrine gland and testis, on astrocytic functions were examined. Mouse cultured astrocytes expressed PK-R1 type PK receptors, while there was little expression of the PK-R2 type. PKs caused increases in astrocytic cytosolic Ca(2+) levels and BrdU incorporation. Increases in Ca(2+) levels by PK-2 were diminished by U73122 (a phospholipase C inhibitor). PK-induced BrdU incorporation was inhibited by U73122, GF109203 (a protein kinase C inhibitor) and PD98059 (a MEK/ERK inhibitor). These results indicate that PK receptors are expressed in astrocytes and regulate astrocytic proliferation. |
