| First Author | Deenick EK | Year | 2005 |
| Journal | Eur J Immunol | Volume | 35 |
| Issue | 10 | Pages | 2949-55 |
| PubMed ID | 16180247 | Mgi Jnum | J:113498 |
| Mgi Id | MGI:3686843 | Doi | 10.1002/eji.200425719 |
| Citation | Deenick EK, et al. (2005) Decision criteria for resolving isotype switching conflicts by B cells. Eur J Immunol 35(10):2949-55 |
| abstractText | Isotype switching by B cells is highly regulated by a group of cytokines including IL-4, IFN-gamma and TGF-beta. A B cell can only express one isotype at a time; however, during an immune response it may be exposed to combinations of stimuli that provide it with conflicting switching instructions. To determine how such cytokine-induced isotype switch conflicts would be resolved, the responses of B cells exposed to multiple cytokines were investigated. To eliminate complications arising from simultaneous effects of switching cytokines on proliferation, division number was used as a reference framework to monitor switching rate. The results show a clear hierarchy in which IFN-gamma is dominant over IL-4, and both IL-4 and IFN-gamma are dominant over TGF-beta. These studies reveal how B cells possess a set of logical decision criteria for dealing with pathogens that invoke a range of different stimuli. |
