| First Author | Kondo M | Year | 1993 |
| Journal | Science | Volume | 262 |
| Issue | 5141 | Pages | 1874-7 |
| PubMed ID | 8266076 | Mgi Jnum | J:113694 |
| Mgi Id | MGI:3687433 | Doi | 10.1126/science.8266076 |
| Citation | Kondo M, et al. (1993) Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. Science 262(5141):1874-7 |
| abstractText | The gamma chain of the interleukin-2 (IL-2) receptor is an indispensable subunit for IL-2 binding and intracellular signal transduction. A monoclonal antibody to the gamma chain, TUGm2, inhibited IL-2 binding to the functional IL-2 receptors and also inhibited IL-4-induced cell growth and the high-affinity binding of IL-4 to the CTLL-2 mouse T cell line. Another monoclonal antibody, TUGm3, which reacted with the gamma chain cross-linked with IL-2, also immunoprecipitated the gamma chain when cross-linked with IL-4. These results suggest that the IL-2 receptor gamma chain is functionally involved in the IL-4 receptor complex. |
