| First Author | Deng CX | Year | 2002 |
| Journal | Oncogene | Volume | 21 |
| Issue | 40 | Pages | 6222-7 |
| PubMed ID | 12214252 | Mgi Jnum | J:113943 |
| Mgi Id | MGI:3687895 | Doi | 10.1038/sj.onc.1205713 |
| Citation | Deng CX (2002) Roles of BRCA1 in centrosome duplication. Oncogene 21(40):6222-7 |
| abstractText | Centrosome duplication is under precise control and occurs only once in a normal mammalian cell cycle. Disruption of this process causes centrosome amplification, unequal segregation of chromosomes and, ultimately, tumorigenesis. Recent studies indicate that breast cancer suppressor gene 1 (BRCA1) plays an important role in regulating centrosome duplication. BRCA1 is located in the centrosome and binds to gamma-tubulin. It interacts with a variety of proteins that regulate centrosome duplication, including BRCA2, CDK2-Cyclin A, CDK2-Cyclin E, Gadd45, p21, p53 and Rb. Furthermore, targeted disruption of murine BRCA1 results in centrosome amplification, suggesting that BRCA1 serves as a negative regulator for centrosome duplication. This review will examine these data and discuss possible relationships between BRCA1 and its interacting proteins in centrosome duplication. |
