| First Author | Fisson S | Year | 2006 |
| Journal | Eur J Immunol | Volume | 36 |
| Issue | 4 | Pages | 817-27 |
| PubMed ID | 16525991 | Mgi Jnum | J:114788 |
| Mgi Id | MGI:3690166 | Doi | 10.1002/eji.200535445 |
| Citation | Fisson S, et al. (2006) Therapeutic potential of self-antigen-specific CD4+ CD25+ regulatory T cells selected in vitro from a polyclonal repertoire. Eur J Immunol 36(4):817-27 |
| abstractText | CD4+ CD25+ regulatory T cells (Treg) play a major role in the prevention of autoimmune diseases. Converging evidence indicates that Treg specific for self-antigens expressed by target tissues have a greater therapeutic potential than polyclonal Treg. Therefore, the selective expansion of rare self-antigen-specific T(reg) naturally present in a polyclonal repertoire of Treg is of major importance. In this work, we investigated the potential of different dendritic cell (DC) subsets to expand antigen-specific Treg in mice. The in vitro selective expansion of rare islet-specific Treg from polyclonal Treg could only be achieved efficiently by stimulation with CD8+ splenic DC presenting islet antigens. These islet-specific Treg exerted potent bystander suppression on diabetogenic T cells and prevented type 1 diabetes. This approach opens new perspectives for cell therapy of autoimmune diseases. |
