| First Author | Grabher C | Year | 2006 |
| Journal | Nat Rev Cancer | Volume | 6 |
| Issue | 5 | Pages | 347-59 |
| PubMed ID | 16612405 | Mgi Jnum | J:114914 |
| Mgi Id | MGI:3690395 | Doi | 10.1038/nrc1880 |
| Citation | Grabher C, et al. (2006) Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia. Nat Rev Cancer 6(5):347-59 |
| abstractText | The chromosomal translocation t(7;9) in human T-cell acute lymphoblastic leukaemia (T-ALL) results in deregulated expression of a truncated, activated form of Notch 1 (TAN1) under the control of the T-cell receptor-beta (TCRB) locus. Although TAN1 efficiently induces T-ALL in mouse models, t(7;9) is present in less than 1% of human T-ALL cases. The recent discovery of novel activating mutations in NOTCH1 in more than 50% of human T-ALL samples has made it clear that Notch 1 is far more important in human T-ALL pathogenesis than previously suspected. |
