| First Author | Keeshan K | Year | 2006 |
| Journal | Cancer Cell | Volume | 10 |
| Issue | 5 | Pages | 401-11 |
| PubMed ID | 17097562 | Mgi Jnum | J:116165 |
| Mgi Id | MGI:3693071 | Doi | 10.1016/j.ccr.2006.09.012 |
| Citation | Keeshan K, et al. (2006) Tribbles homolog 2 inactivates C/EBPalpha and causes acute myelogenous leukemia. Cancer Cell 10(5):401-11 |
| abstractText | Tribbles homolog 2 (Trib2) was identified as a downregulated transcript in leukemic cells undergoing growth arrest. To investigate the effects of Trib2 in hematopoietic progenitors, mice were reconstituted with hematopoietic stem cells retrovirally expressing Trib2. Trib2-transduced bone marrow cells exhibited a growth advantage ex vivo and readily established factor-dependent cell lines. In vivo, Trib2-reconstituted mice uniformly developed fatal transplantable acute myelogenous leukemia (AML). In mechanistic studies, we found that Trib2 associated with and inhibited C/EBPalpha. Furthermore, Trib2 expression was elevated in a subset of human AML patient samples. Together, our data identify Trib2 as an oncogene that induces AML through a mechanism involving inactivation of C/EBPalpha. |
