| First Author | Sommermeyer D | Year | 2006 |
| Journal | Eur J Immunol | Volume | 36 |
| Issue | 11 | Pages | 3052-9 |
| PubMed ID | 17051621 | Mgi Jnum | J:117007 |
| Mgi Id | MGI:3695362 | Doi | 10.1002/eji.200636539 |
| Citation | Sommermeyer D, et al. (2006) Designer T cells by T cell receptor replacement. Eur J Immunol 36(11):3052-9 |
| abstractText | T cell receptor (TCR) gene transfer is a convenient method to produce antigen-specific T cells for adoptive therapy. However, the expression of two TCR in T cells could impair their function or cause unwanted effects by mixed TCR heterodimers. With five different TCR and four different T cells, either mouse or human, we show that some TCR are strong--in terms of cell surface expression--and replace weak TCR on the cell surface, resulting in exchange of antigen specificity. Two strong TCR are co-expressed. A mouse TCR replaces human TCR on human T cells. Even though it is still poorly understood why some TCRalpha/beta combinations are preferentially expressed on T cells, our data suggest that, in the future, designer T cells with exclusive tumor reactivity can be generated by T cell engineering. |
