| First Author | Gu D | Year | 2007 |
| Journal | FEBS Lett | Volume | 581 |
| Issue | 3 | Pages | 382-8 |
| PubMed ID | 17239862 | Mgi Jnum | J:118212 |
| Mgi Id | MGI:3698919 | Doi | 10.1016/j.febslet.2006.12.043 |
| Citation | Gu D, et al. (2007) The effect of pleiotrophin signaling on adipogenesis. FEBS Lett 581(3):382-8 |
| abstractText | Pleiotrophin (PTN) plays diverse roles in cell growth and differentiation. In this investigation, we demonstrate that PTN plays a negative role in adipogensis and that glycogen synthase kinase 3beta (GSK-3beta) and beta-catenin are involved in the regulation of PTN-mediated preadipocyte differentiation. Knocking down the expression of PTN using siRNA resulted in an increase in phospho-GSK-3beta expression, and the accumulation of nuclear beta-catenin, which are critical downstream signaling proteins for both the PTN and Wnt signaling pathways. Our investigation suggests that there is a PTN/PI3K/AKT/GSK-3beta/beta-catenin signaling pathway, which cross-talks with the Wnt/Fz/GSK-3beta/beta-catenin pathway and negatively regulates adipogenesis. |
