| First Author | Zhang T | Year | 2007 |
| Journal | Biochem Biophys Res Commun | Volume | 355 |
| Issue | 2 | Pages | 444-50 |
| PubMed ID | 17300750 | Mgi Jnum | J:118632 |
| Mgi Id | MGI:3699995 | Doi | 10.1016/j.bbrc.2007.01.170 |
| Citation | Zhang T, et al. (2007) Cardiac-specific overexpression of SCN5A gene leads to shorter P wave duration and PR interval in transgenic mice. Biochem Biophys Res Commun 355(2):444-50 |
| abstractText | The Cardiac sodium channel gene SCN5A plays a critical role in cardiac electrophysiology and its mutations, either gain- or loss-of-functions, are associated with lethal arrhythmias. In this study, we investigated the effect of overexpression of SCN5A on the cardiac phenotype in a transgenic mouse model (TG-WT L10). Compared to NTG mice, heart rate, QRS duration, and QT intervals remained unchanged in TG-WT mice. Moreover, no spontaneous ventricular arrhythmias were detected in TG-WT hearts. Despite these results, a mild, irregular cardiac phenotype was observed in TG-WT mice. The P wave and PR interval were significantly shorter in TG-WT compared with NTG mice (P, 8.8+/-0.8ms vs. 12.6+/-0.9ms; PR, 12.5+/-2ms vs. 33.5+/-0.7ms). Furthermore, spontaneous premature atrial contractions were often detected in TG-WT mice. These results suggest that the expression level of the SCN5A gene is a determinant for the length of the P wave duration and PR interval on electrocardiograms (ECG). |
