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Publication : Growth factor-binding proteases in the murine submaxillary gland: isolation of a cDNA clone.

First Author  Ronne H Year  1983
Journal  EMBO J Volume  2
Issue  9 Pages  1561-4
PubMed ID  11892812 Mgi Jnum  J:32386
Mgi Id  MGI:79883 Doi  10.1002/j.1460-2075.1983.tb01624.x
Citation  Ronne H, et al. (1983) Growth factor-binding proteases in the murine submaxillary gland: isolation of a cDNA clone. EMBO J 2(9):1561-4
abstractText  The submaxillary gland of the adult male mouse contains a number of serine proteases, several of which are involved in the proteolytic processing of precursors to growth factors and other biologically active polypeptides. Here we report the isolation and identification of a cDNA clone corresponding to one of the proteases, the type B of the epidermal growth factor-binding protein. A pronounced sequence homology was found between the predicted activation peptide of this protease and the NH2-terminal extension of the nerve growth factor alpha subunit, suggesting that the latter protein has an uncleaved activation peptide attached to its NH2 terminus.
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