| First Author | Meixlsperger S | Year | 2007 |
| Journal | Immunity | Volume | 26 |
| Issue | 3 | Pages | 323-33 |
| PubMed ID | 17331747 | Mgi Jnum | J:119771 |
| Mgi Id | MGI:3703253 | Doi | 10.1016/j.immuni.2007.01.012 |
| Citation | Meixlsperger S, et al. (2007) Conventional light chains inhibit the autonomous signaling capacity of the B cell receptor. Immunity 26(3):323-33 |
| abstractText | Signals from the B cell antigen receptor (BCR), consisting of mu heavy chain (muHC) and conventional light chain (LC), and its precursor the pre-BCR, consisting of muHC and surrogate light chain (SLC), via the adaptor protein SLP-65 regulate the development and function of B cells. Here, we compare the effect of SLC and conventional LC expression on receptor-induced Ca(2+) flux in B cells expressing an inducible form of SLP-65. We found that SLC expression strongly enhanced an autonomous ability of muHC to induce Ca(2+) flux irrespective of additional receptor crosslinking. In contrast, LC expression reduced this autonomous muHC ability and resulted in antigen-dependent Ca(2+) flux. These data indicate that autonomous ligand-independent signaling can be induced by receptor forms other than the pre-BCR. In addition, our data suggest that conventional LCs play an important role in the inhibition of autonomous receptor signaling, thereby allowing further B cell differentiation. |
