| First Author | Karalis KP | Year | 1999 |
| Journal | Proc Natl Acad Sci U S A | Volume | 96 |
| Issue | 12 | Pages | 7093-7 |
| PubMed ID | 10359844 | Mgi Jnum | J:123712 |
| Mgi Id | MGI:3719320 | Doi | 10.1073/pnas.96.12.7093 |
| Citation | Karalis KP, et al. (1999) Corticotropin-releasing hormone deficiency unmasks the proinflammatory effect of epinephrine. Proc Natl Acad Sci U S A 96(12):7093-7 |
| abstractText | Traditionally, the adrenal gland has been considered an important endocrine component of the pathway to inhibit acute inflammation via hypothalamic corticotropin-releasing hormone (CRH)-mediated secretion of glucocorticoid. Immunoreactive CRH found in inflamed tissues is a potent proinflammatory factor. Using genetic and pharmacological models of CRH deficiency, we now show that CRH deficiency unmasks a major proinflammatory effect of epinephrine secreted from the adrenal medulla. Together, epinephrine and peripheral CRH stimulate inflammation, and glucocorticoid acts as a counterbalancing force in this regard. Our findings suggest that stimulation of the acute inflammatory response should be included with the other 'fight-or-flight' actions of epinephrine. |
