| First Author | Jaworski M | Year | 2007 |
| Journal | Int J Cancer | Volume | 121 |
| Issue | 6 | Pages | 1382-5 |
| PubMed ID | 17514646 | Mgi Jnum | J:125411 |
| Mgi Id | MGI:3758499 | Doi | 10.1002/ijc.22801 |
| Citation | Jaworski M, et al. (2007) Global gene expression in Ha-ras and B-raf mutated mouse liver tumors. Int J Cancer 121(6):1382-5 |
| abstractText | Chemically-induced mouse liver tumors harbor mutations in different oncogenes. About 50% of tumors contain activating mutations in the Ha-ras gene contain and about 20% of tumors show point mutations in the B-raf oncogene. We have investigated the gene expression profiles in tumors of the 2 genotypes by microarray analysis. In total, approximately 500 genes or expressed sequences were aberrantly expressed in tumors relative to normal liver tissue. Around two/thirds of them were significantly altered in both Ha-ras and B-raf mutated liver tumors, and most of the remaining genes showed at least qualitatively comparable changes in both tumor types. Several functional clusters were hypothesized in tumors of the 2 genotypes which involve alterations in a battery of genes encoding enzymes of lipid metabolism. The similarity in the patterns of global gene expression of Ha-ras and B-raf mutated liver tumors suggests that mutational activation of the 2 oncogenes results in activation of a common set of transcriptional regulators. |
