| First Author | Murata Y | Year | 2007 |
| Journal | Biochem Biophys Res Commun | Volume | 364 |
| Issue | 2 | Pages | 301-7 |
| PubMed ID | 17950694 | Mgi Jnum | J:127426 |
| Mgi Id | MGI:3763749 | Doi | 10.1016/j.bbrc.2007.10.007 |
| Citation | Murata Y, et al. (2007) IRS-1 transgenic mice show increased epididymal fat mass and insulin resistance. Biochem Biophys Res Commun 364(2):301-7 |
| abstractText | Insulin receptor substrate-1 (IRS-1) is the major substrate of both the insulin receptor and the IGF-1 receptor. In this study, we created IRS-1 transgenic (IRS-1-Tg) mice which express human IRS-1 cDNA under control of the mouse IRS-1 gene promoter. In the IRS-1-Tg mice, IRS-1 mRNA expression was significantly increased in almost all tissues, but its protein expression was increased in very limited tissues (epididymal fat and skeletal muscle). IRS-1-Tg mice showed glucose intolerance and significantly enlarged epididymal fat mass, as well as elevated serum TNF-alpha concentrations. Importantly insulin signaling was significantly attenuated in the liver of IRS-1-Tg mice, which may contribute to the glucose intolerance. Our results suggest that excess IRS-1 expression may not provide a beneficial impact on glucose homeostasis in vivo. |
