| First Author | Emerling BM | Year | 2007 |
| Journal | FEBS Lett | Volume | 581 |
| Issue | 29 | Pages | 5727-31 |
| PubMed ID | 18036344 | Mgi Jnum | J:127730 |
| Mgi Id | MGI:3764753 | Doi | 10.1016/j.febslet.2007.11.038 |
| Citation | Emerling BM, et al. (2007) Compound C inhibits hypoxic activation of HIF-1 independent of AMPK. FEBS Lett 581(29):5727-31 |
| abstractText | The key transcription factor that regulates the cellular responses to hypoxia is hypoxia inducible factor-1 (HIF-1). The signaling mechanisms that regulate the hypoxic activation of HIF-1 are not fully understood. Our objective here was to test whether AMP-activated kinase (AMPK) was an upstream regulator of HIF-1. Our results show that AMPK is not required for the hypoxic activation of HIF-1. Interestingly, the AMPK inhibitor, Compound C, inhibits the hypoxic activation of HIF-1 independent of AMPK. Furthermore, we demonstrate that Compound C functions as a repressor of HIF-1 by inhibiting respiration and suppressing mitochondrial generated ROS. |
