| First Author | Glenn G | Year | 2007 |
| Journal | FEBS Lett | Volume | 581 |
| Issue | 28 | Pages | 5377-81 |
| PubMed ID | 17967422 | Mgi Jnum | J:127741 |
| Mgi Id | MGI:3764764 | Doi | 10.1016/j.febslet.2007.10.031 |
| Citation | Glenn G, et al. (2007) CSF-1 and TPA stimulate independent pathways leading to lysosomal degradation or regulated intramembrane proteolysis of the CSF-1 receptor. FEBS Lett 581(28):5377-81 |
| abstractText | The CSF-1 receptor is a protein-tyrosine kinase that has been shown to undergo regulated intramembrane proteolysis, or RIPping. Here, we have compared receptor downregulation and RIPping in response to CSF-1 and TPA. Our studies show that CSF-1 is a relatively poor inducer of RIPping and that CSF-1-induced receptor downregulation is largely independent of RIPping. TPA is a strong inducer of RIPping and TPA-induced receptor downregulation is mediated by RIPping. We further found that RIPping is dependent on TACE or a TACE-like protease, that CSF-1 and TPA use independent pathways to initiate RIPping, and that the intracellular domain is targeted for degradation through ubiquitination. |
