| First Author | Bebo BF Jr | Year | 2000 |
| Journal | Cytokine | Volume | 12 |
| Issue | 4 | Pages | 324-31 |
| PubMed ID | 10805212 | Mgi Jnum | J:127818 |
| Mgi Id | MGI:3765109 | Doi | 10.1006/cyto.1999.0564 |
| Citation | Bebo BF Jr, et al. (2000) Interleukin 7 is a potent co-stimulator of myelin specific T cells that enhances the adoptive transfer of experimental autoimmune encephalomyelitis. Cytokine 12(4):324-31 |
| abstractText | Interleukin 7 (IL-7), originally described as a B cell growth factor, has recently been found to play a critical role in T and B lymphocyte development and function. This study evaluated the effects of IL-7 on myelin specific T cells. IL-7 strongly enhanced proliferation of proteolipid protein (PLP) 139-151 specific T cells in association with elevated secretion of the T cell growth factor IL-2. Co-stimulation with IL-7 preferentially increased the levels of pro-inflammatory cytokines secreted by PLP 139-151 specific T cells and adoptive transfer of these cells into naive recipients induced a profound enhancement of experimental autoimmune encephalomyelitis, an animal model for the human disease multiple sclerosis. These results suggest that IL-7 may be a critical co-stimulatory factor that enhances the extrathymic expansion of inflammatory T cells and may play an important role in the pathogenesis of a number of inflammatory autoimmune disorders. |
