| First Author | Bommareddy A | Year | 2007 |
| Journal | Anticancer Res | Volume | 27 |
| Issue | 4B | Pages | 2185-8 |
| PubMed ID | 17695502 | Mgi Jnum | J:128613 |
| Mgi Id | MGI:3767545 | Citation | Bommareddy A, et al. (2007) Chemoprevention by alpha-santalol on UVB radiation-induced skin tumor development in mice. Anticancer Res 27(4B):2185-8 |
| abstractText | Studies have shown the chemopreventive effects of alpha-santalol on chemically and UVB-induced skin cancer in mice. The objective of the present investigation was to find the lowest effective concentration of alpha-santalol for the chemopreventive effects on UVB-induced skin tumor development in mice and to determine antiperoxidant effect of alpha-santalol in order to elucidate its possible mechanism of action. Female SKH-1 mice were divided into different groups receiving either vehicle alone or different concentrations of alpha-santalol. Mice in all the groups were initiated and promoted with UVB radiation for skin tumor development. The promotion phase continued for 30 weeks. Skin tumors were counted once a week for 30 weeks. Lipid peroxidation was assayed in skin and liver microsomes by measuring malonaldehyde formed using thiobarbituric acid method. Topical administration of alpha-santalol reduced UVB-induced skin tumor development in a concentration-dependent manner. Application of alpha-santalol (5%) significantly (p < 0.05) delayed skin tumor development for 25 weeks and reduced tumor multiplicity. alpha-Santalol also inhibited in vitro lipid peroxidation in skin and liver microsomes. alpha-Santalol application prevents UVB-induced skin tumor development possibly by acting as an antiperoxidant. |
