| First Author | Strle K | Year | 2007 |
| Journal | J Neuroimmunol | Volume | 188 |
| Issue | 1-2 | Pages | 48-55 |
| PubMed ID | 17572510 | Mgi Jnum | J:128876 |
| Mgi Id | MGI:3768215 | Doi | 10.1016/j.jneuroim.2007.05.003 |
| Citation | Strle K, et al. (2007) Novel activity of an anti-inflammatory cytokine: IL-10 prevents TNFalpha-induced resistance to IGF-I in myoblasts. J Neuroimmunol 188(1-2):48-55 |
| abstractText | IL-10 is an anti-inflammatory cytokine that suppresses synthesis of proinflammatory cytokines and their receptors. Here we tested the possibility that TNFalpha-induced hormone resistance in myoblasts might be overcome by IL-10. We found that IL-10 restores myogenesis by suppressing the ability of exogenous TNFalpha to inhibit IGF-I-induced myogenin. This protection occurs without decreasing global activity of TNF receptors since IL-10 does not impair TNFalpha-induced IL-6 synthesis or ERK1/2 phosphorylation. Instead, IL-10 acts to prevent TNFalpha-induced phosphorylation of JNK. These findings demonstrate that IL-10 serves a previously unrecognized protective role in muscle progenitors by overcoming TNFalpha-induced resistance to IGF-I. |
