| First Author | Jüttler E | Year | 2007 |
| Journal | J Neuroimmunol | Volume | 189 |
| Issue | 1-2 | Pages | 41-9 |
| PubMed ID | 17655939 | Mgi Jnum | J:128971 |
| Mgi Id | MGI:3768451 | Doi | 10.1016/j.jneuroim.2007.06.020 |
| Citation | Juttler E, et al. (2007) Neuronal NF-kappaB influences thermoregulation and survival in a sepsis model. J Neuroimmunol 189(1-2):41-9 |
| abstractText | Gene regulation in sepsis is known to be controlled by the transcription factor NF-kappaB. However, the function of neuronal NF-kappaB in sepsis is not well defined. In a mouse model of sepsis induced by i.p. injection of lipopolysaccharides (LPS), we found an activation of NF-kappaB in the brain as shown by the induction of a transgenic NF-kappaB reporter. Inhibition of neuronal NF-kappaB by cell-specific expression of the NF-kappaB super-repressor IkappaBalpha-SR improved LPS-induced hypothermia and survival but had no effect on body weight or on the humoral response to LPS. In contrast, glial inhibition of NF-kappaB did not influence body temperature and survival. By immunohistochemistry, we detected the active NF-kappaB subunit RelA in neuronal nuclei of the organum vasculosum of the lamina terminalis. Our data reveal an important role of neuronal NF-kappaB in thermoregulation and survival. The upcoming group of NF-kappaB inhibitors may have a place in the treatment of the acute-phase response. |
