| First Author | Guan Y | Year | 2007 |
| Journal | J Neuroimmunol | Volume | 192 |
| Issue | 1-2 | Pages | 68-78 |
| PubMed ID | 18006080 | Mgi Jnum | J:130119 |
| Mgi Id | MGI:3771079 | Doi | 10.1016/j.jneuroim.2007.09.021 |
| Citation | Guan Y, et al. (2007) Antigen presenting cells treated in vitro by macrophage colony-stimulating factor and autoantigen protect mice from autoimmunity. J Neuroimmunol 192(1-2):68-78 |
| abstractText | Macrophage colony-stimulating factor (M-CSF) is a critical cytokine in the development of monocytic lineage and may have immunoregulatory properties. Here we show that peritoneal antigen presenting cells (APCs) treated with M-CSF produced decreased levels of proinflammatory cytokines IFN-gamma, TNF-alpha and IL-12. These APCs treated with M-CSF+autoantigen peptide significantly suppressed antigen-specific T cell proliferation, induced regulatory CD4(+) and CD8(+) T cells in vitro and in vivo, and significantly suppressed experimental autoimmune encephalomyelitis (EAE). Thus, in vitro treatment of APCs with M-CSF+autoantigen can be a novel therapeutic option for autoimmune diseases. |
