| First Author | Bracchi-Ricard V | Year | 2008 |
| Journal | J Neurochem | Volume | 104 |
| Issue | 3 | Pages | 611-23 |
| PubMed ID | 17953667 | Mgi Jnum | J:130650 |
| Mgi Id | MGI:3772032 | Doi | 10.1111/j.1471-4159.2007.04993.x |
| Citation | Bracchi-Ricard V, et al. (2008) Astroglial nuclear factor-kappaB regulates learning and memory and synaptic plasticity in female mice. J Neurochem 104(3):611-23 |
| abstractText | Astrocytes play a pivotal role in regulating synaptic plasticity and synapse formation. The nuclear factor-kappa B (NF-kappaB) family of transcription factors has recently been demonstrated to be an important modulator of synaptic plasticity and learning/memory. In this study, we investigated the role of astroglial NF-kappaB in synaptic plasticity and learning/memory using transgenic mice over-expressing an N-terminal truncated form of inhibitor of NF-kappaB alpha (IkappaBalpha) in astrocytes (GFAP-IkappaBetaalpha-dn). We demonstrated that female transgenic mice, but not males, have robust deficits in hippocampal and extra-hippocampal-dependent learning and memory. We also determined that there are significant deficits in LTP and expression of metabotropic glutamate receptor 5 and post-synaptic density protein 95 (PSD95) in female transgenic mice. These findings indicate that astroglial NF-kappaB is an important regulator of learning/memory and synaptic plasticity. |
