| First Author | Ray D | Year | 2008 |
| Journal | Cancer Res | Volume | 68 |
| Issue | 5 | Pages | 1251-3 |
| PubMed ID | 18316586 | Mgi Jnum | J:132763 |
| Mgi Id | MGI:3776931 | Doi | 10.1158/0008-5472.CAN-07-5983 |
| Citation | Ray D, et al. (2008) CDC25A phosphatase: a rate-limiting oncogene that determines genomic stability. Cancer Res 68(5):1251-3 |
| abstractText | CDC25A is a critical regulator of cell cycle progression and checkpoint response. Overexpression of this cyclin-dependent kinase phosphatase occurs often in human cancers. Our recent genetic studies in the mouse indicate that restricting CDC25A can limit tumorigenesis induced by the HER2/neu-RAS oncogenic pathway without compromising normal cell division or viability. These findings offer a sound foundation to justify development of CDC25A inhibitors for antitumor therapy. |
