| First Author | Beck-Engeser GB | Year | 2008 |
| Journal | Retrovirology | Volume | 5 |
| Pages | 4 | PubMed ID | 18194563 |
| Mgi Jnum | J:134054 | Mgi Id | MGI:3784905 |
| Doi | 10.1186/1742-4690-5-4 | Citation | Beck-Engeser GB, et al. (2008) Pvt1-encoded microRNAs in oncogenesis. Retrovirology 5:4 |
| abstractText | BACKGROUND: The functional significance of the Pvt1 locus in the oncogenesis of Burkitt's lymphoma and plasmacytomas has remained a puzzle. In these tumors, Pvt1 is the site of reciprocal translocations to immunoglobulin loci. Although the locus encodes a number of alternative transcripts, no protein or regulatory RNA products were found. The recent identification of non-coding microRNAs encoded within the PVT1 region has suggested a regulatory role for this locus. RESULTS: The mouse Pvt1 locus encodes several microRNAs. In mouse T cell lymphomas induced by retroviral insertions into the locus, the Pvt1 transcripts, and at least one of their microRNA products, mmu-miR-1204 are overexpressed. Whereas up to seven co-mutations can be found in a single tumor, in over 2,000 tumors none had insertions into both the Myc and Pvt1 loci. CONCLUSION: Judging from the large number of integrations into the Pvt1 locus - more than in the nearby Myc locus - Pvt1 and the microRNAs encoded by it are as important as Myc in T lymphomagenesis, and, presumably, in T cell activation. An analysis of the co-mutations in the lymphomas likely place Pvt1 and Myc into the same pathway. |
