| First Author | Sheng MH | Year | 2008 |
| Journal | FEBS Lett | Volume | 582 |
| Issue | 10 | Pages | 1451-8 |
| PubMed ID | 18381073 | Mgi Jnum | J:134263 |
| Mgi Id | MGI:3785204 | Doi | 10.1016/j.febslet.2008.03.030 |
| Citation | Sheng MH, et al. (2008) Osteoactivin is a novel osteoclastic protein and plays a key role in osteoclast differentiation and activity. FEBS Lett 582(10):1451-8 |
| abstractText | This study presents gene expression, protein expression, and in situ immunohistochemical evidence that osteoclasts express high levels of osteoactivin (OA), which had previously been reported to be an osteoblast-specific protein in bone. OA expression in osteoclasts was up-regulated upon receptor activator of NFkappaB ligand-induced differentiation. Suppression of functional activity of OA with neutralizing antibody reduced cell size, number of nuclei, fusion, and bone resorption activity of osteoclasts. OA was co-immunoprecipitated with integrin beta(3) and beta(1), indicating that OA co-localizes with integrin beta(3) and/or beta(1) in a hetero-polymeric complex in osteoclasts. These findings indicate that OA is a novel osteoclastic protein and plays a role in osteoclast differentiation and/or activity. |
