| First Author | Reinwald S | Year | 2008 |
| Journal | J Immunol | Volume | 180 |
| Issue | 9 | Pages | 5890-7 |
| PubMed ID | 18424708 | Mgi Jnum | J:134317 |
| Mgi Id | MGI:3785318 | Doi | 10.4049/jimmunol.180.9.5890 |
| Citation | Reinwald S, et al. (2008) CD83 Expression in CD4+ T Cells Modulates Inflammation and Autoimmunity. J Immunol 180(9):5890-7 |
| abstractText | The transmembrane protein CD83 has been initially described as a maturation marker for dendritic cells. Moreover, there is increasing evidence that CD83 also regulates B cell function, thymic T cell maturation, and peripheral T cell activation. Herein, we show that CD83 expression confers immunosuppressive function to CD4(+) T cells. CD83 mRNA is differentially expressed in naturally occurring CD4(+)CD25(+) regulatory T cells, and upon activation these cells rapidly express large amounts of surface CD83. Transduction of naive CD4(+)CD25(-) T cells with CD83 encoding retroviruses induces a regulatory phenotype in vitro, which is accompanied by the induction of Foxp3. Functional analysis of CD83-transduced T cells in vivo demonstrates that these CD83(+)Foxp3(+) T cells are able to interfere with the effector phase of severe contact hypersensitivity reaction of the skin. Moreover, adoptive transfer of these cells prevents the paralysis associated with experimental autoimmune encephalomyelitis, suppresses proinflammatory cytokines IFN-gamma and IL-17, and increases antiinflammatory IL-10 in recipient mice. Taken together, our data provide the first evidence that CD83 expression can contribute to the immunosuppressive function of CD4(+) T cells in vivo. |
