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Publication : Epstein-Barr virus nuclear antigen 1 does not cause lymphoma in C57BL/6J mice.

First Author  Kang MS Year  2008
Journal  J Virol Volume  82
Issue  8 Pages  4180-3
PubMed ID  18256159 Mgi Jnum  J:135524
Mgi Id  MGI:3793991 Doi  10.1128/JVI.02596-07
Citation  Kang MS, et al. (2008) Epstein-Barr virus nuclear antigen 1 does not cause lymphoma in C57BL/6J mice. J Virol 82(8):4180-3
abstractText  To test whether transgenic Epstein-Barr virus nuclear antigen 1 (EBNA1) expression in C57BL/6 mouse lymphocytes causes lymphoma, EBNA1 expressed in three FVB lineages at two or three times the level of latent infection was crossed up to six successive times into C57BL/6J mice. After five or six crosses, 14/36, (38%) EBNA1 transgenic mice, 11/31 (36%) littermate EBNA1-negative controls, and 9/25 (36%) inbred C57BL/6J mice housed in the same facility had lymphoma. These data indicate that EBNA1 does not significantly increase lymphoma prevalence in C57BL/6J mice.
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