First Author | Kang MS | Year | 2008 |
Journal | J Virol | Volume | 82 |
Issue | 8 | Pages | 4180-3 |
PubMed ID | 18256159 | Mgi Jnum | J:135524 |
Mgi Id | MGI:3793991 | Doi | 10.1128/JVI.02596-07 |
Citation | Kang MS, et al. (2008) Epstein-Barr virus nuclear antigen 1 does not cause lymphoma in C57BL/6J mice. J Virol 82(8):4180-3 |
abstractText | To test whether transgenic Epstein-Barr virus nuclear antigen 1 (EBNA1) expression in C57BL/6 mouse lymphocytes causes lymphoma, EBNA1 expressed in three FVB lineages at two or three times the level of latent infection was crossed up to six successive times into C57BL/6J mice. After five or six crosses, 14/36, (38%) EBNA1 transgenic mice, 11/31 (36%) littermate EBNA1-negative controls, and 9/25 (36%) inbred C57BL/6J mice housed in the same facility had lymphoma. These data indicate that EBNA1 does not significantly increase lymphoma prevalence in C57BL/6J mice. |