| First Author | Lee JM | Year | 2008 |
| Journal | FEBS Lett | Volume | 582 |
| Issue | 13 | Pages | 1871-6 |
| PubMed ID | 18474237 | Mgi Jnum | J:136201 |
| Mgi Id | MGI:3795625 | Doi | 10.1016/j.febslet.2008.04.056 |
| Citation | Lee JM, et al. (2008) The involvement of caspase-11 in TPEN-induced apoptosis. FEBS Lett 582(13):1871-6 |
| abstractText | The depletion of intracellular zinc with N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) induces protein synthesis-dependent apoptosis. Here we examined the involvement of caspase induction in apoptosis. Among the examined caspases, only caspase-11 was increased by TPEN. Caspase-11 activity also increased, which resulted in caspase-3 activation. Cycloheximide or actinomycin D blocked caspase-11 induction, reduced caspase-11 and -3 activation, and attenuated TPEN-induced neuronal apoptosis. Blockade of caspase-11 by a chemical inhibitor or genetic deletion attenuated TPEN-induced apoptosis, indicating a critical role of caspase-11 in TPEN-induced apoptosis. Although mitochondria-mediated caspase-9/-3 activation also contributed to TPEN-induced apoptosis, caspase-11 is likely a key inducible apoptosis-inducing protein. |
