| First Author | Gros MJ | Year | 2008 |
| Journal | J Immunol | Volume | 180 |
| Issue | 12 | Pages | 8153-8 |
| PubMed ID | 18523280 | Mgi Jnum | J:137233 |
| Mgi Id | MGI:3798358 | Doi | 10.4049/jimmunol.180.12.8153 |
| Citation | Gros MJ, et al. (2008) Cell intrinsic TGF-beta1 regulation of B cells. J Immunol 180(12):8153-8 |
| abstractText | TGF-beta family cytokines play multiple roles in immune responses. TGF-beta1-null mice suffer from multi-organ infiltration that leads to their premature death. T cells play a central role in the TGF-beta1 phenotype, as deficiency of TGF-beta1 only in T cells reproduces the lethal phenotype. Although it is known that TGF-beta1 controls B cells isotype switch and homeostasis, the source responsible for this control has not been characterized. Because of the major role that T cells play in regulating B cell responses, we addressed the T cell dependency of the TGF-beta1 control of B cells. The analysis of T cell-deficient, TGF-beta1 knockout mice and the production of chimeras in which B but not T cells lacked TGF-beta1 allowed us to show that B cells are controlled in part by cell autonomous production of TGF-beta1. |
