| First Author | Chiu FL | Year | 2008 |
| Journal | FEBS Lett | Volume | 582 |
| Issue | 16 | Pages | 2407-12 |
| PubMed ID | 18544347 | Mgi Jnum | J:137378 |
| Mgi Id | MGI:3799408 | Doi | 10.1016/j.febslet.2008.05.049 |
| Citation | Chiu FL, et al. (2008) Tomatidine inhibits iNOS and COX-2 through suppression of NF-kappaB and JNK pathways in LPS-stimulated mouse macrophages. FEBS Lett 582(16):2407-12 |
| abstractText | We use the LPS-stimulated macrophage as a model of inflammation to investigate the anti-inflammatory effects of tomatidine and solasodine, whose structures resemble glucocorticoids. We found that tomatidine exhibited a more potent anti-inflammatory effect than solasodine. Tomatidine could decrease inducible nitric oxide synthase and cyclooxygenase-2 expression through suppression of I-kappaBalpha phosphorylation, NF-kappaB nuclear translocation and JNK activation, which in turn inhibits c-jun phosphorylation and Oct-2 expression. Here, we demonstrate that tomatidine acts as an anti-inflammatory agent by blocking NF-kappaB and JNK signaling, and may possibly be developed as a useful agent for the chemoprevention of cancer or inflammatory diseases. |
