| First Author | Miyamae T | Year | 2006 |
| Journal | J Immunol | Volume | 177 |
| Issue | 7 | Pages | 4758-62 |
| PubMed ID | 16982916 | Mgi Jnum | J:139310 |
| Mgi Id | MGI:3807735 | Doi | 10.4049/jimmunol.177.7.4758 |
| Citation | Miyamae T, et al. (2006) Follistatin-like protein-1 is a novel proinflammatory molecule. J Immunol 177(7):4758-62 |
| abstractText | While analyzing gene expression in collagen-induced arthritis, we discovered that a poorly characterized gene, follistatin-like protein 1 (FSTL-1), is highly overexpressed in mouse paws during early arthritis, especially at the interface of synovial pannus and eroding bone. In this study, we show that FSTL-1 is a novel proinflammatory molecule with a previously unrecognized role in inflammation. Transfection of FSTL-1 into macrophages and fibroblasts leads to up-regulation of proinflammatory cytokines, including IL-1beta, TNF-alpha, and IL-6. Overexpression of FSTL-1 in mouse paws by gene transfer results in severe paw swelling and arthritis. |
