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Publication : Bone morphogenetic protein signaling in the developing kidney: present and future.

First Author  Cain JE Year  2008
Journal  Differentiation Volume  76
Issue  8 Pages  831-42
PubMed ID  18331343 Mgi Jnum  J:139602
Mgi Id  MGI:3808955 Doi  10.1111/j.1432-0436.2008.00265.x
Citation  Cain JE, et al. (2008) Bone morphogenetic protein signaling in the developing kidney: present and future. Differentiation 76(8):831-42
abstractText  Bone morphogenetic proteins (BMPs) are members of the transforming growth factor-beta superfamily. A critical role for BMP signaling in the development of the metanephric kidney is supported by a growing number of studies using in vitro assays and in vivo animal models. Here we review current knowledge of BMPs, BMP receptors and regulators of the BMP signaling pathway in the developing kidney. We highlight major gaps in our knowledge of the roles of BMP signaling in the development of the normal and abnormal kidney and identify areas and techniques likely to improve our understanding.
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