| First Author | Wang GJ | Year | 2008 |
| Journal | J Immunol | Volume | 181 |
| Issue | 8 | Pages | 5242-8 |
| PubMed ID | 18832678 | Mgi Jnum | J:140093 |
| Mgi Id | MGI:3811933 | Doi | 10.4049/jimmunol.181.8.5242 |
| Citation | Wang GJ, et al. (2008) Thymus exosomes-like particles induce regulatory T cells. J Immunol 181(8):5242-8 |
| abstractText | Exosomes released from different types of cells have been proposed to contribute to intercellular communication. We report that thymic exosome-like particles (ELPs) released from cells of the thymus can induce the development of Foxp3(+) regulatory T (Treg) cells in the lung and liver. Thymic ELPs also induce the conversion of thymic CD4(+)CD25(-) T cells into Tregs. Tregs induced by thymic ELPs suppress the proliferation of CD4(+)CD25(-) T cells in vitro and in vivo. We further show that neutralization of TGF-beta in ELPs partially reverses thymic ELP-mediated induction of CD4(+)Foxp3(+) T cells in the lung and liver. This study demonstrates that thymic ELPs participate in the induction of Foxp3(+) Tregs. Also, TGF-beta of thymic ELPs might be required for the generation of Tregs in the peripheral tissues. |
