| First Author | Ohuchi H | Year | 2008 |
| Journal | Dev Dyn | Volume | 237 |
| Issue | 11 | Pages | 3280-94 |
| PubMed ID | 18924241 | Mgi Jnum | J:140656 |
| Mgi Id | MGI:3814271 | Doi | 10.1002/dvdy.21736 |
| Citation | Ohuchi H, et al. (2008) Expression patterns of the lysophospholipid receptor genes during mouse early development. Dev Dyn 237(11):3280-94 |
| abstractText | Lysophospholipids (LPs) such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) are known to mediate various biological responses, including cell proliferation, migration, and differentiation. To better understand the role of these lipids in mammalian early development, we applied whole-mount in situ hybridization techniques to E8.5 to E12.5 mouse embryos. We determined the expression patterns of the following LP receptor genes, which belong to the G protein-coupled receptor (GPCR) family: EDG1 to EDG8 (S1P(1) to S1P(5) and LPA(1) to LPA(3)), LPA(4) (GPR23 /P2Y9), and LPA(5) (GPR92). We found that the S1P/LPA receptor genes exhibit overlapping expression patterns in a variety of organ primordia, including the developing brain and cardiovascular system, presomitic mesoderm and somites, branchial arches, and limb buds. These results suggest that multiple receptor systems for LPA/S1P lysophospholipids may be functioning during organogenesis. Developmental Dynamics 237:3280-3294, 2008. (c) 2008 Wiley-Liss, Inc. |
