| First Author | Yamashita M | Year | 2008 |
| Journal | Mol Cell | Volume | 31 |
| Issue | 6 | Pages | 918-24 |
| PubMed ID | 18922473 | Mgi Jnum | J:141094 |
| Mgi Id | MGI:3815365 | Doi | 10.1016/j.molcel.2008.09.002 |
| Citation | Yamashita M, et al. (2008) TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta. Mol Cell 31(6):918-24 |
| abstractText | In many physiological and disease processes, TGF-beta usurps branches of MAP kinase pathways in conjunction with Smads to induce apoptosis and epithelial-to-mesenchymal transition, but the detailed mechanism of how a MAP kinase cascade is activated by TGF-beta receptors is not clear. We report here that TRAF6 is specifically required for the Smad-independent activation of JNK and p38, and its carboxyl TRAF homology domain physically interacts with TGF-beta receptors. TGF-beta induces K63-linked ubiquitination of TRAF6 and promotes association between TRAF6 and TAK1. Our results indicate that TGF-beta activates JNK and p38 through a mechanism similar to that operating in the interleukin-1beta/Toll-like receptor pathway. |
