| First Author | Lum AM | Year | 2007 |
| Journal | Retrovirology | Volume | 4 |
| Pages | 5 | PubMed ID | 17442096 |
| Mgi Jnum | J:147190 | Mgi Id | MGI:3839660 |
| Doi | 10.1186/1742-4690-4-5 | Citation | Lum AM, et al. (2007) Retroviral activation of the mir-106a microRNA cistron in T lymphoma. Retrovirology 4:5 |
| abstractText | Retroviral insertion into a host genome is a powerful tool not only for the discovery of cancer genes, but also for the discovery of potential oncogenic noncoding RNAs. In a large-scale mouse T lymphocyte tumor screen we found a high density of integrations upstream of the mir-106a microRNA cistron. In tumors containing an integration, the primary transcript encoding the mir-106a cistron was overexpressed five to 20-fold compared with that of control tumors; concomitantly, the mature mir-106a and mir-363 microRNAs were highly overexpressed as well. These findings suggest the mir-106a cistron plays an important role in T cell tumorigenesis. |
