| First Author | Argellati F | Year | 2009 |
| Journal | FASEB J | Volume | 23 |
| Issue | 4 | Pages | 1246-51 |
| PubMed ID | 19103644 | Mgi Jnum | J:147312 |
| Mgi Id | MGI:3840052 | Doi | 10.1096/fj.08-119263 |
| Citation | Argellati F, et al. (2009) Protein kinase C-dependent alpha-secretory processing of the amyloid precursor protein is mediated by phosphorylation of myosin II-B. FASEB J 23(4):1246-51 |
| abstractText | A substantial body of evidence indicates that protein kinase C (PKC) is involved in the alpha-secretory processing of the amyloid precursor protein (APP), an event that reduces the formation of the pathogenic amyloid-beta peptide. Recently, we have shown that trafficking and processing of APP are both impaired by knockdown of myosin II-B, one of the major neuronal motor proteins. Here, we provide evidence that the alpha-secretory processing of APP is mediated by PKC-dependent phosphorylation of myosin II-B. This signaling pathway provides an important link between APP and the neuronal cytoskeleton and might be crucial for the understanding of the biological and pathological roles of APP. |
