| First Author | Sekiyama K | Year | 2009 |
| Journal | Biochem Biophys Res Commun | Volume | 385 |
| Issue | 3 | Pages | 319-23 |
| PubMed ID | 19463785 | Mgi Jnum | J:150676 |
| Mgi Id | MGI:3851300 | Doi | 10.1016/j.bbrc.2009.05.054 |
| Citation | Sekiyama K, et al. (2009) Abnormalities in aggression and anxiety in transgenic mice overexpressing activin E. Biochem Biophys Res Commun 385(3):319-23 |
| abstractText | To study the function of activin E, a TGF-beta superfamily member, in the regulation of affective behavior, we investigated the behavior of transgenic mice overexpressing activin E (TgActbetaE mice). Male TgActbetaE mice showed aggressive behavior in resident-intruder tests. In elevated plus-maze tests, the percentage of open arm entries was significantly increased in female TgActbetaE mice compared with that in wild-type mice. Furthermore, female TgActbetaE mice stayed in the central area for a significantly longer time than wild-type mice in open field tests. These results indicated that TgActbetaE mice had less anxiety-like behavior. The number of restraint-stress-evoked c-Fos-positive cells in the hypothalamic paraventricular nucleus in TgActbetaE mice was significantly decreased compared with that in wild-type mice. This suggests that synthesis of corticotrophin-releasing hormone induced by stress was decreased in TgActbetaE mice. Taking these results together, activin E may act as a regulator of the hypothalamic-pituitary-adrenal axis. |
