| First Author | Ecker K | Year | 2009 |
| Journal | Nat Cell Biol | Volume | 11 |
| Issue | 4 | Pages | 377-9 |
| PubMed ID | 19337320 | Mgi Jnum | J:155073 |
| Mgi Id | MGI:4412226 | Doi | 10.1038/ncb0409-377 |
| Citation | Ecker K, et al. (2009) Skp2: caught in the Akt. Nat Cell Biol 11(4):377-9 |
| abstractText | To control cell proliferation, signal transduction needs to regulate the cell-cycle machinery. Recent findings show that Akt - a major kinase that coordinates diverse signalling pathways - phosphorylates Skp2, a subunit of the SCF-Skp2 ubiquitin ligase that targets key cell-cycle regulators. Akt1-dependent phosphorylation activates SCF-Skp2 through multiple mechanisms. |
