| First Author | Park H | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 1 | Pages | 173-80 |
| PubMed ID | 19925797 | Mgi Jnum | J:155553 |
| Mgi Id | MGI:4414714 | Doi | 10.1016/j.febslet.2009.11.043 |
| Citation | Park H, et al. (2010) PDE4 inhibitor upregulates PTH-induced osteoclast formation via CRE-mediated COX-2 expression in osteoblasts. FEBS Lett 584(1):173-80 |
| abstractText | We investigated the interplay between parathyroid hormone (PTH) and phosphodiesterases (PDEs) in osteoblasts. PDE4 negatively regulated PTH-induced cAMP accumulation. PDE4 inhibitor enhanced PTH-induced osteoclast formation and RANKL mRNA expression, which is partially mediated by COX-2 mRNA expression. Two CRE sites in the COX-2 promoter were required for the increase in COX-2 transcription by PDE4 inhibitor, and the expression of a dominant-negative form of CREB abolished COX-2 mRNA expression in response to PDE4 inhibitor or PTH in osteoblasts. Taken together, our data indicate that PDE4 inhibitor promotes PTH-induced osteoclast formation partially via CRE-mediated COX-2 mRNA expression. |
