| First Author | Cao H | Year | 2010 |
| Journal | Mol Cell Biol | Volume | 30 |
| Issue | 3 | Pages | 781-92 |
| PubMed ID | 19995918 | Mgi Jnum | J:156491 |
| Mgi Id | MGI:4420729 | Doi | 10.1128/MCB.00330-09 |
| Citation | Cao H, et al. (2010) SRC-mediated phosphorylation of dynamin and cortactin regulates the 'constitutive' endocytosis of transferrin. Mol Cell Biol 30(3):781-92 |
| abstractText | The mechanisms by which epithelial cells regulate clathrin-mediated endocytosis (CME) of transferrin are poorly defined and generally viewed as a constitutive process that occurs continuously without regulatory constraints. In this study, we demonstrate for the first time that endocytosis of the transferrin receptor is a regulated process that requires activated Src kinase and, subsequently, phosphorylation of two important components of the endocytic machinery, namely, the large GTPase dynamin 2 (Dyn2) and its associated actin-binding protein, cortactin (Cort). To our knowledge these findings are among the first to implicate an Src-mediated endocytic cascade in what was previously presumed to be a nonregulated internalization process. |
