| First Author | Doma E | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 5 | Pages | 1033-40 |
| PubMed ID | 20138036 | Mgi Jnum | J:157525 |
| Mgi Id | MGI:4431090 | Doi | 10.1016/j.febslet.2010.01.059 |
| Citation | Doma E, et al. (2010) A novel role of microtubular cytoskeleton in the dynamics of caspase-dependent Fas/CD95 death receptor complexes during apoptosis. FEBS Lett 584(5):1033-40 |
| abstractText | The activation of cysteine-aspartic proteases or caspases and the dynamic arrangement of cytoskeletal components are crucial during apoptosis. Here we describe the fate of Fas downstream of the FasL-induced internalization step, including formation of caspase-dependent SDS-stable Fas complexes, which is mediated by cytoskeleton integrity. We show, in particular, that following FasL treatment, the Fas lower aggregate complex can be co-immunoprecipitated with tubulin and an active form of caspase-8 and that this interaction contributes to the propagation of FasL-induced cell death. The importance of cytoskeletal components during FasL-induced apoptosis is highlighted by our detection of a pool of microtubule-associated Fas complexes. |
