| First Author | Meng G | Year | 2010 |
| Journal | Eur J Immunol | Volume | 40 |
| Issue | 3 | Pages | 649-53 |
| PubMed ID | 20201022 | Mgi Jnum | J:157822 |
| Mgi Id | MGI:4437137 | Doi | 10.1002/eji.200940191 |
| Citation | Meng G, et al. (2010) New insights into the nature of autoinflammatory diseases from mice with Nlrp3 mutations. Eur J Immunol 40(3):649-53 |
| abstractText | Mutations in the Nlrp3 (CIAS1, cryopyrin) gene are associated with cryopyrin-associated periodic syndrome, autoinflammatory diseases characterized by excessive IL-1 production and neutrophilia in blood and tissues. Recent studies with gene-targeted mice expressing mutations homologous to those found in cryopyrin-associated periodic syndrome patients have advanced the understanding of NLRP3-associated autoinflammation. In this Viewpoint, we will discuss the mechanisms of NLRP3 inflammasome activation and its induction of Th17-cell-dominant immunologic responses. |
