| First Author | Bikkavilli RK | Year | 2010 |
| Journal | J Cell Sci | Volume | 123 |
| Issue | Pt 8 | Pages | 1352-62 |
| PubMed ID | 20332102 | Mgi Jnum | J:159634 |
| Mgi Id | MGI:4452184 | Doi | 10.1242/jcs.056176 |
| Citation | Bikkavilli RK, et al. (2010) Dishevelled-KSRP complex regulates Wnt signaling through post-transcriptional stabilization of beta-catenin mRNA. J Cell Sci 123(Pt 8):1352-62 |
| abstractText | Canonical Wnt/beta-catenin signaling is crucial during embryonic development. Upon Wnt stimulation, Dishevelled proteins relay the signal from upstream Frizzled receptors to downstream effectors. By using affinity purification followed by ion-trap mass spectrometry we identified K-homology splicing regulator protein (KSRP) as a novel Dishevelled-interacting protein. We show that KSRP negatively regulates Wnt/beta-catenin signaling at the level of post-transcriptional CTNNB1 (beta-catenin) mRNA stability. Thus, Dishevelled-KSRP complex operates in Wnt regulation of beta-catenin, functioning post-transcriptionally upon CTNNB1 mRNA stability. |
