| First Author | Choi HH | Year | 2010 |
| Journal | FEBS Lett | Volume | 584 |
| Issue | 11 | Pages | 2445-54 |
| PubMed ID | 20416295 | Mgi Jnum | J:160307 |
| Mgi Id | MGI:4454216 | Doi | 10.1016/j.febslet.2010.04.050 |
| Citation | Choi HH, et al. (2010) Endoplasmic reticulum stress response is involved in Mycobacterium tuberculosis protein ESAT-6-mediated apoptosis. FEBS Lett 584(11):2445-54 |
| abstractText | Mycobacterium tuberculosis (Mtb) infection leads to the induction of the apoptotic response, which is associated with bacilli killing. The early secreted mycobacterial antigen ESAT-6 of Mtb has been shown to induce apoptosis in human macrophages and epithelial cells. In the present study, we demonstrate that the stimulation of human epithelial A549 cells by ESAT-6 induces the endoplasmic reticulum (ER) stress response. We observed that ESAT-6 treatment increases intracellular Ca(2+) concentration, which results in ROS accumulation, and therefore induces the onset of ER stress-induced apoptosis. Our results uncover a novel apoptotic mechanism of ESAT-6 through ER stress responses in pathologic conditions such as tuberculosis. |
