| First Author | Arai D | Year | 2010 |
| Journal | Dev Biol | Volume | 341 |
| Issue | 2 | Pages | 459-63 |
| PubMed ID | 20227405 | Mgi Jnum | J:160490 |
| Mgi Id | MGI:4454519 | Doi | 10.1016/j.ydbio.2010.03.002 |
| Citation | Arai D, et al. (2010) Polycomb group protein Ezh1 represses Nodal and maintains the left-right axis. Dev Biol 341(2):459-63 |
| abstractText | The left-right (LR) axis is essential for the proper function of internal organs. In mammals and fish, left-sided Nodal expression governs LR patterning. Here, we show that the Polycomb group protein Ezh1, which is highly conserved from fish to human, participates in LR patterning. Knockdown of olezh1, a medaka homologue of Ezh1, led to LR reversal of internal organs. It was shown that OLEZH1 acts in silencing the expression of Spaw (a medaka homolog of Nodal) via a previously unknown pathway. Furthermore, coimmunoprecipitation showed physical interaction of Ezh1 with FoxH1, a Nodal regulator. This represents a novel mechanism for LR patterning and implies that Ezh1 has developmental importance. |
