| First Author | Rouleau M | Year | 2010 |
| Journal | Nat Rev Cancer | Volume | 10 |
| Issue | 4 | Pages | 293-301 |
| PubMed ID | 20200537 | Mgi Jnum | J:160779 |
| Mgi Id | MGI:4455096 | Doi | 10.1038/nrc2812 |
| Citation | Rouleau M, et al. (2010) PARP inhibition: PARP1 and beyond. Nat Rev Cancer 10(4):293-301 |
| abstractText | Recent findings have thrust poly(ADP-ribose) polymerases (PARPs) into the limelight as potential chemotherapeutic targets. To provide a framework for understanding these recent observations, we review what is known about the structures and functions of the family of PARP enzymes, and then outline a series of questions that should be addressed to guide the rational development of PARP inhibitors as anticancer agents. |
