| First Author | Xu JF | Year | 2010 |
| Journal | Clin Immunol | Volume | 136 |
| Issue | 1 | Pages | 30-41 |
| PubMed ID | 20346734 | Mgi Jnum | J:160848 |
| Mgi Id | MGI:4455252 | Doi | 10.1016/j.clim.2010.02.022 |
| Citation | Xu JF, et al. (2010) Ectopic B7-H4-Ig expression attenuates concanavalin A-induced hepatic injury. Clin Immunol 136(1):30-41 |
| abstractText | Previous studies demonstrate that both membrane B7-H4 and B7-H4-Ig fusion protein could inhibit T-cell responses. In the present study, we explored the potential effect of B7-H4-Ig on liver injury in a hepatitis mouse model induced by concanavalin A (ConA). A B7-H4-Ig construct was introduced into animals by the hydrodynamic gene delivery approach. It was found that ectopic expression of B7-H4-Ig could inhibit ConA-induced elevation of serum levels of ALT and AST, suppress liver necrosis and even mortality of mice. Furthermore, we observed that pretreatment of B7-H4-Ig dramatically decreased serum levels and the expression of mRNA for IL-2, IFN-gamma and IL-4, but increased IL-10 in ConA-treated mice. Our results suggest that B7-H4-Ig may protect animals from liver injury induced by ConA, which could be associated with reduced serum levels for IL-2, IFN-gamma and IL-4 as well as enhanced IL-10 production. |
