| First Author | Huang S | Year | 2009 |
| Journal | Cancer Cell | Volume | 15 |
| Issue | 4 | Pages | 328-40 |
| PubMed ID | 19345331 | Mgi Jnum | J:161099 |
| Mgi Id | MGI:4457236 | Doi | 10.1016/j.ccr.2009.02.023 |
| Citation | Huang S, et al. (2009) ZNF423 is critically required for retinoic acid-induced differentiation and is a marker of neuroblastoma outcome. Cancer Cell 15(4):328-40 |
| abstractText | Retinoids play key roles in differentiation, growth arrest, and apoptosis and are increasingly being used in the clinic for the treatment of a variety of cancers, including neuroblastoma. Here, using a large-scale RNA interference-based genetic screen, we identify ZNF423 (also known as Ebfaz, OAZ, or Zfp423) as a component critically required for retinoic acid (RA)-induced differentiation. ZNF423 associates with the RARalpha/RXRalpha nuclear receptor complex and is essential for transactivation in response to retinoids. Downregulation of ZNF423 expression by RNA interference in neuroblastoma cells results in a growth advantage and resistance to RA-induced differentiation, whereas overexpression of ZNF423 leads to growth inhibition and enhanced differentiation. Finally, we show that low ZNF423 expression is associated with poor disease outcome in neuroblastoma patients. |
